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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
PARKINSON S DISEASE-RELATED BIOMARKERS THAT MAY APPEAR IN AMPHETAMINES ABUSERS
العلامات البيولوجية المتعلقة بمرض باركينسون (الشلل الرعاشي) والتي قد تظهر في مدمني مادة الأمفيتامين
Subject
:
faculty of Applied Medical Sciences
Document Language
:
Arabic
Abstract
:
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. It is characterized by the degeneration of dopaminergic substantia nigra pars compacta neurons. Amphetamine addiction may cause a serious of psychotic and physical damages to humans. There is some evidence showed that amphetamine may increase the risk of PD. Thus, this study aimed to compare the PD serum biomarkers between amphetamine addicts and PD patients and utilized them as diagnostic biomarkers to early detect of PD incidence among amphetamine addicts. In the current study, seventeen-amphetamine addicts, aged <40 were recruited from Al Amal Psychiatric hospital, Jazan, Saudi Arabia. Nineteen PD patients, and 19 healthy controls, never take amphetamine, were also recruited. Blood samples were withdrawn from all groups. Biomarkers multiplex assay from Milliplex was used to assess the levels of serum amyloid-P (SAP), complement C4, C-reactive protein (CRP) and CRP/albumin ratio in serum samples (Vitros 350® slide was used to assess the albumin). All data were statistically analyzed using one way ANOVA. The results showed that SAP and CRP levels were significantly higher in amphetamine addicts compared to healthy controls (p= 0.0001, p= 0.0001, respectively). The results of amphetamine addicts were comparable to PD levels. However, there are no significant differences between all studied groups concerning complement C4 level. Moreover, albumin levels were significantly decreased and CRP/Albumin ratio levels were significantly increased in amphetamine addicts (p= 0.00 and p= 0.041, respectively) in contrast with controls. These findings indicate that the increased level of these inflammatory biomarkers (SAP and CRP) in the amphetamine addicts may give a potential possibility of their serum level to be used as screening markers to detect PD development in the amphetamine addict. It may be useful to evaluate the changes in easily accessible and cost-effective parameters such as serum CRP/albumin ratio.
Supervisor
:
Dr Aziza Al-Rafiah
Thesis Type
:
Master Thesis
Publishing Year
:
1441 AH
2020 AD
Added Date
:
Thursday, June 25, 2020
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
محمد محمد الكعبي
Al-Kaabi, Mohammed Mohammed
Researcher
Master
Files
File Name
Type
Description
46521.pdf
pdf
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