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Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
UTILITY OF ACTIVE METHYLENE COMPOUNDS IN THE SYNTHESIS OF SOME NEW HETEROCYCLIC COMPOUNDS WITH EXPECTED BIOLOGICAL ACTIVITY
استخدام مركبات الميثيلين النشطة في تحضير بعض المركبات الحلقية غير المتجانسة الجديدة ذات النشاط البيولوجي المتوقع
Subject
:
Faculty of Sciences
Document Language
:
Arabic
Abstract
:
The present work represents the synthesis of a new series of highly functionalized 1-alkyl-6-amino-4-aryl (or het)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles 4a-q via one-pot three-component reaction of diverse aldehydes 2a-f, N-alkyl-2-cyanoacetamides 1a-c and malononitrile (3) in EtOH in the presence of K2CO3 as a base catalyst under thermal and microwave irradiation. The presented tandem process is expected to proceed via Knoevenagel condensation, Michael addition, intramolecular cyclization, autoxidation and subsequent aromatization. The structures of all the newly synthesized compounds in this work were unambiguously confirmed by IR, NMR (1H and 13C), mass spectral data and elemental analyses.
Supervisor
:
Dr. Mariam Abdullah AL-Sheikh
Thesis Type
:
Master Thesis
Publishing Year
:
1439 AH
2018 AD
Added Date
:
Monday, July 9, 2018
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
نجلاء حسين السفياني
Alsofyani, Najla Hosain
Researcher
Master
Files
File Name
Type
Description
43581.pdf
pdf
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