Main Page
Deanship
The Dean
Dean's Word
Curriculum Vitae
Contact the Dean
Vision and Mission
Organizational Structure
Vice- Deanship
Vice- Dean
KAU Graduate Studies
Research Services & Courses
Research Services Unit
Important Research for Society
Deanship's Services
FAQs
Research
Staff Directory
Files
Favorite Websites
Deanship Access Map
Graduate Studies Awards
Deanship's Staff
Staff Directory
Files
Researches
Contact us
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Histological Changes in Rats Liver Induced by Different Doses of Diclofenac Sodium and the Ameliorative Effects of the herb Moringa Oleifera
التغيرات النسيجية لكبد الجرذان المستحدثة بجرعات مختلفة من عقارالديكلوفيناك الصوديوم والتاثيرات التحسنية لعشب المورينجا
Subject
:
Faculty of Sciences > biological sciences department
Document Language
:
Arabic
Abstract
:
Diclofenac sodium or Voltaren is a nonsteroidal antiinflammatory drug (NSAID) widely used for treatment of a variety of disorders, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute muscle pain., hepatic injury is one of the health hazards resulting from oxidative damage. The main objective of the present study was to find if Moringa oleifera a novel hepatoprotective can amolerate histological and biochemical changes evoked by both acute effects of large doses of DIC(50,100,150mg/kg ) or chronic use of therapeutic dose 8 mg /kg . 9 groups of animals each group 10 rats were used in this study :control group I,G2I :8mg/kg, G2IIa:50mg/kg, G 2II b:100mg/kg, G 2II c: 150mg/kg, G3I: 8mg/kg+MO, G3IIa: 50mg/kg+MO, G3II b:100mg/kg+MO , G3II c:150mg/kg+MO. Biochemical studies showed significant alteration in liver function tests as increased serum alanine aminotransferase (ALT), aspartate aminotransferase (AST)and alkaline phosphatase(ALP) which are dose and duration dependant .Light microscopic changes in the form of sinusoidal dilation and congestion, bile duct proliferation . mild lymphocyte infiltration were observed and were dose and duration dependant. ultra structure changes showed cytoplasmic regions of degenerated organelles appeared as irregular moderate electron dense masses with lucent centers , some mitochondrial alteration ,prominent Vonkupffer cells and lipid droplets within ito cells. Conclusion administration with water Moringa oleifera extract before DIC treatment significantly ameliorated the indices of hepatotoxicity induced by DIC. these results suggest that MO inhibit DIC induced hepatotoxicity
Supervisor
:
Dr.Nevine Abdel Azim Refaat
Thesis Type
:
Master Thesis
Publishing Year
:
1435 AH
2014 AD
Added Date
:
Wednesday, July 2, 2014
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ميسون محمد المغربي
AL-mograbi, Maysoon Mohammad
Researcher
Master
Files
File Name
Type
Description
37165.pdf
pdf
Back To Researches Page