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Document Details
Document Type
:
Article In Journal
Document Title
:
protective effect of ascorbic acid on cisplatin genotoxicity in male mice bone marrow cells
تأثير وقائي من حمض الاسكوربيك على السمية الجينية في سيسبلاتين ذكر الفئران خلايا نخاع العظام
Subject
:
protective effect of ascorbic acid on cisplatin genotoxicity in male mice bone marrow cells
Document Language
:
English
Abstract
:
Cisplatin (cis-diamminedichloroplatinum II) is an effective antitumor agent with a wide spectrum of activity against varies solid tumors, but it has serious side effects on nontumour cells. Cisplatin produces intra- and interstrand DNA cross-linking effects and chromosomal aberrations in mammalian cells. Vitamin C (ascorbic acid) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA, from oxidative damage induced by different agents. Pretreatment administration of ascorbic acid on cisplatin induced chromosome aberrations has been determined in bone marrow cells of Swiss albino mice. Results showed that cisplatin (7.5 & 10mg/kg bw)IP injection to male mice induced significant increase in the frequencies of chromosomal aberrations. The results of pre-treatment with ascorbic acid (66mg/kg bw) showed a significant decrease in the number of chromosomal aberrations induced with cisplatin tested doses. Ascorbic acid did not exhibit any clastogenic effect in male mice bone marrow cells. We concluded that ascorbic acid has a protective role against the genotoxicity induced by antitumor drug cisplatin.
ISSN
:
2411-0013
Journal Name
:
Egyptian Medical Journal
Volume
:
18
Issue Number
:
1
Publishing Year
:
1425 AH
2005 AD
Article Type
:
Article
Added Date
:
Wednesday, February 20, 2013
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ندى حسن التواتي
Touati, Nada Hassan
Investigator
Doctorate
naltwaty@yahoo.com
Files
File Name
Type
Description
35057.pdf
pdf
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