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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Simultaneous onset of steroid resistant nephrotic syndrome and IDDM in two young children
Simultaneous onset of steroid resistant nephrotic syndrome and IDDM in two young children
Subject
:
Pediatric Nephrology
Document Language
:
English
Abstract
:
The cases are reported of two young children who developed insulin-dependent diabetes mellitus (IDDM) within 2 weeks of receiving a diagnosis of nephrotic syndrome. Neither patient responded to 8 weeks of daily prednisolone. The first patient presented at 2 years and 9 months of age. Her renal biopsy showed mesangial proliferation. The second child presented with steroid resistant nephrotic syndrome at 18 months of age and developed IDDM 2 weeks later. He achieved partial remission with cyclosporine therapy. His initial renal biopsy at 3 years of age showed minimal change disease and follow-up renal biopsy at 5 years of age showed early diabetic glomerulosclerosis. Tests for NPHS2 and WT1 genetic mutations were negative in both patients. To our knowledge this is the first report of steroid resistant nephrotic syndrome with almost simultaneous onset of IDDM in young children
ISSN
:
1757-790X
Journal Name
:
BMJ Case Reports
Volume
:
9
Issue Number
:
4
Publishing Year
:
1431 AH
2010 AD
Article Type
:
Case Report
Added Date
:
Sunday, July 10, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
جميلة قاري
Kari, Jameela
Investigator
Doctorate
jkari@doctors.org.uk
شريف الدسوقي
El-Desoky, Sherif
Researcher
Doctorate
غدير مختار
Mokhtar, Ghadeer
Researcher
Doctorate
سوسن جللة
Jalalah, Sawsan
Researcher
Doctorate
Files
File Name
Type
Description
29936.pdf
pdf
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