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Document Details
Document Type
:
Article In Journal
Document Title
:
Ultrastructural studies on the changes induced by toxic effect of Doxorubicin on rat hepatocyte and protective role of Dexrazoxane
التركيبية دراسات عن التغييرات الناجمة عن التأثير السمي للدوكسوروبيسين الكبدية على الفئران ودورا وقائيا من ديكسرازوكسان
Subject
:
Ultrastructural studies on the changes induced by toxic effect of Doxorubicin on rat hepatocyte and protective role of Dexrazoxane
Document Language
:
English
Abstract
:
The anthracycline antibiotic Doxorubicin is one of the most effective antitumour agents used to treat human malignancies. Long term treatment with DOX is limited by its hepatotoxicity. The purpose of the present investigation was to evaluate the hepatotoxic effect of the drug when used alone or combined with the iron-chelating agent Dexrazoxane (DXZ) as protective effect. Twenty four adult male rats were divided into 3 groups: Control group, group2A, Doxorubicin 1 week (DOX 1 wk), group2B, Doxorubicin 2 weeks (DOX 2wk) and group3, Doxorubicin +Dexrazoxane (DOX+DXZ 1 wk. and 2 wk.). Ultrastructural damage showed hepatocytes injury after 1 week and more severed after 2 wk as Hepatocyte cell appears with vacuolated with damage mitochondria structures and vacuolated in nucleus. Liver cell disappear some cytoplasm organelles such as rough endoplasmic reticulum, smooth endoplasmic reticulum and lysosomes.
ISSN
:
1012-1319
Journal Name
:
Science Journal
Volume
:
5
Issue Number
:
1
Publishing Year
:
1428 AH
2008 AD
Article Type
:
Article
Added Date
:
Monday, February 28, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
اسامة ابو زنادة
abu zenadh, osamh
Researcher
Doctorate
Files
File Name
Type
Description
29174.pdf
pdf
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