Main Page
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Science and Arts - Khulais
Document Details
Document Type
:
Article In Journal
Document Title
:
LOW MOLECULAR WEIGHT SEA ANEMONE GYROSTOMA HELLAYTHUS NEUROTOXINS FROM THE RED SEA
سموم شقائق النعمان البحرية قليلة الوزن الجزئى من البحر الأحمر
Document Language
:
Arabic
Abstract
:
The crude aqueous ethanolic extract of the collected sea anemone samples Gyrostoma helianthus were partially evaporated followed by freeze-drying. The freeze-dried material dissolved in water showed neurotoxicity to mice after i.p. injection of I ml (20 mg/ml). Mouse bioassay was used to follow the toxicity of the crude extract of sea anemone during purification by ultrafiltration through a membrane filter with a molecular weight exclusion cut off 10, 5, 3, 1 and 0.5 K Dalton. Toxicity was detected till the final filtrate of less than 0.5 K Dalton. The toxicity level was determined in Mouse Units for each membrane filtrate. The dry weights of these filtrates were also determined. Mouse bioassay was used to follow the toxicity of the freeze-dried filtrate (less than 500 dalton) after fiactionation on Biogel P2. Two different toxic compounds were detected in the Biogel P2 fractions. An HPLC method was adopted to detect the HPLC peak responsible for toxicity in order to trace the toxic compounds in further purification steps and to determine percent purity of the isolated toxic compounds
ISSN
:
34567
Journal Name
:
Journal of Egyptian society for Toxicity
Volume
:
43
Issue Number
:
1
Publishing Year
:
1420 AH
1999 AD
Article Type
:
Article
Added Date
:
Saturday, January 8, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
محمد نصر الدين محمد جمعة
Gomaa, Mohamed Nasr Eldin mohamed
Investigator
Doctorate
mngomaa@gmail.com
Files
File Name
Type
Description
28520.pdf
pdf
Back To Researches Page