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Faculty of Science and Arts - Khulais
Document Details
Document Type
:
Article In Journal
Document Title
:
NEUROTOXICITY OF SEA ANEMONE GYROSTOMA HELIANTHUS FROM THE RED SEA
السمية العصبية لنعمان البحر جيروستوما هيليانثس
Document Language
:
Arabic
Abstract
:
The scientific names of the collected sea anemone samples were confirmed as Entacmaea quadricolor (Rueppellx Leuckant, 1828) or Gyrostoma helianthus (Hemprich and Ehrenberg 1834). The collected samples were obtained from the Red Sea at the vicinity of Hurghada. The crude aqueous ethanolic extract of the collected sea anemone was freeze-dried to be used in the determination of the Dose Response Curve in mice after i.p. injection. The profile of this curve showed that the threshold was at 20 mg/ml and a plateau at 28 mg/ml. The estimated LDJQ values of the Sea Anemone crude extract were " 19.28, 24.7 and 27.3 pg/insect for M.domestica, C.pipens and S.littoralis respectively while it was 732.8 mg/kg for mice when i.p. injected. On the other hand, the tested crude extract at the dose level 1/8 LD50 when i.p. injected in 20 g mice showed potent inhibitory effect against AchE activity in both brain and blood of mice. Maximum inhibition was recorded 30 min after treatment. Throughout the test period the enzyme activity showed tendency to restore its original value. No activity was detected against the tested bacterial and fungal species as well as against brine shrimp.
ISSN
:
3456
Journal Name
:
Journal of Egyptian society for Toxicity
Volume
:
22
Issue Number
:
1
Publishing Year
:
1420 AH
2000 AD
Article Type
:
Article
Added Date
:
Saturday, January 8, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
محمد نصر الدين محمد جمعة
Gomaa, Mohamed Nasr Eldin mohamed
Investigator
Doctorate
mngomaa@gmail.com
Files
File Name
Type
Description
28518.pdf
pdf
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