Document Details
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Document Type |
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Thesis |
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Document Title |
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EFFECTS OF SOME PLANT OILS ON PHYSIOLOGICAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS تأثيرات بعض الزيوت النباتية على المعايير الفسيولوجية في الجرذان المصابة بداء السكري المستحث بالستريبتوزوتوسين |
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Subject |
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Biological |
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Document Language |
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Arabic |
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Abstract |
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The present study was carried out to investigate the effect of the oils of black seed, cinnamon, olive and ginger on some physiological parameters in normal and streptozotocin (STZ)-induced diabetic male Wistar rats. Diabetes was induced in adult male Wistar rats (180–230 g) by a single intraperitoneal injection of STZ (65 mg/kg body weight). 160 rats (120 surviving diabetic rats and 40 normal rats) were used in the experiment. The rats were divided into 16 groups of 10 rats each as follows: Group 1 served as normal control and fed normal commercial chow; Group 2 served as diabetic control and fed the same diet given in Group 1; The diabetic groups 3, 4, 5 and 6 were fed diets containing by weight: black seed, cinnamon, olive and ginger oils at the levels of 5% for each, respectively, and Similarly, the normal non-diabetic groups 13, 14, 15 and 16 were fed diets containing by weight: black seed, cinnamon, olive and ginger oils at the levels of 5% for each, respectively, while the diabetic groups 7, 8, 9, 10, 11 and 12 were fed diets containing a mixture of two different types of oils at the levels of 2.5% for each, respectively. Rats were fed the experimental diets for 7 weeks. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein (LDL-cholesterol), uric acid, urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) while body weight, body temperature, high density lipoprotein (HDL-cholesterol) and total protein levels were significantly decreased compared to normal control. Administration of the tested oils to diabetic rats resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL–cholesterol and ALT while body temperature and HDL–cholesterol levels were markedly increased compared to untreated diabetic rats after 7 weeks of treatment. Also administration of the tested oils except black seed plus ginger, cinnamon plus olive and cinnamon plus ginger oils to diabetic rats caused a significant increase in body weight compared to untreated diabetic rats. The oils of black seed plus olive, black seed plus cinnamon, black seed plus ginger, and ginger restored the altered blood total protein level to near normal levels. In addition, treatment of STZ-induced diabetic rats with olive, ginger and olive plus ginger oils resulted in a significant decrease in the levels of urea, while the oils of cinnamon, olive plus ginger, black seed plus cinnamon, black seed plus ginger and cinnamon plus ginger lead to significant decreases in the levels of creatinine in STZ-induced diabetic rats compared to untreated diabetic rats. In contrast, uric acid levels were significantly decreased in diabetic rats treated with black seed oil only. The results of this study indicate that the tested oils possess hypoglycemic, hypolipidemic and antioxidant effects in STZ-induced diabetic rats and suggest that these oils may be a useful supplemental remedy in diabetes. |
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Supervisor |
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Prof. Dr. Talal Ali Zari |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1430 AH
2009 AD |
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Added Date |
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Sunday, December 5, 2010 |
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Researchers
| عايد شريف اللقماني | AL-LOGMANI, AYED SHARIEF | Researcher | Doctorate | |
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