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Document Details
Document Type
:
Project
Document Title
:
Evaluation of the methods for tissue-based detection of the Her2/neu gene alteration in human breast cancer
تقييم الطرق التحليلية لتحديد وكشف التغيرات المصاحبة للطفرة الجينية Her2 لمرضى سرطان الثدي.
Subject
:
Evaluation of the methods for tissue-based detection of the Her2/neu gene alteration in human breast cancer
Document Language
:
Arabic
Abstract
:
HER-2 is a protoncogene located on chromosome 17. It encodes a transmembrane growth factor receptor with tyrosine kinase activity. Overexpression and/or amplification of HER-2 are detected in approximately 20% to 30% of invasive ductal carcinomas of the breast and have been associated with a poor prognosis.3 Amplification of the HER-2 oncogene and concomitant overexpression of protein are currently implicated in breast carcinoma as important biomarkers for predicting response to trastuzumab (Herceptin, Roche, Basel, Switzerland), which has signifgicant anti-tumour activity both as single agent and in combination with chemotherapy in these patients. For this reason, laboratory assessment of HER-2 status is becoming a key step in the optimal management t of patients with advanced breast cancer. Immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) have emerged as the two most widely used assays to evaluate HER-2 status in breast cancer. Both methods are recommended by national and international guidelines. Our aim will determine the aneusomy level and the HER-2 gene copy numbers, by fluorescence in situ hybridization (FISH) and to analyze their impact on the amplification rate in breast carcinomas considered HER-2 weekly positive cases by immunohistochemistry.
Publishing Year
:
1427 AH
2006 AD
Sponsor Name
:
King Abdulaziz University
Sponsorship Year
:
1427 AH
2006 AD
Added Date
:
Monday, June 28, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عبد الحكيم محمد كيلاني
Kelany, Abdelhakim Mohammed
Investigator
Doctorate
Files
File Name
Type
Description
27173.docx
docx
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