Main Page
Welcome
About the Center
About The SPC
Mission and Vision
Organizational Structure
Spc Directors
Facts and Figures
Services
ِActivities
Exhibitions
Print Exhibition
Books Exhibition
Visits
Training
Workshops
Courses
Seminars
Conventions
Celebrations
Research
Favorite Links
Contact Us
PhotoAlbum
Contact Us
Researches
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Scientific Publishing Center
Document Details
Document Type
:
Article In Journal
Document Title
:
The Role of Janus Kinase 2 (JAK2) in the Pathologenesis of Myeloproliferative Disorders
دور التايروسين كاينيز في تطور سرطان الدم المزمن
Document Language
:
English
Abstract
:
The myeloproliferative disorders, polycythemia vera, essential thombocythemia, and primary myelofibrosis are clonal disorders of multipotent hematopoietic progenitors. The genetic cause of these diseases was not known until 2005, when several independent groups demonstrated that most patients with PV, ET and PMF acquired a single point mutation in the cytoplasmic tyrosine kinase, such as JAK2 (JAK2 V617F). These discoveries have changed the landscape for diagnosis and classification of PV, ET and PMF, and have shown the ability of genomic technologies to identify new molecular targets in human malignancies with pathogenetic, diagnostic and therapeutic significance.
ISSN
:
1319-1004
Journal Name
:
Medical Science Journal
Volume
:
16
Issue Number
:
1
Publishing Year
:
1430 AH
2009 AD
Article Type
:
Article
Added Date
:
Sunday, January 17, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ممدوح عبدالله قارى
Gari, Mamdooh A.
Researcher
Doctorate
m_gari@hotmail.com
Files
File Name
Type
Description
24857.pdf
pdf
Back To Researches Page