Main Page
Welcome
About the Center
About The SPC
Mission and Vision
Organizational Structure
Spc Directors
Facts and Figures
Services
ِActivities
Exhibitions
Print Exhibition
Books Exhibition
Visits
Training
Workshops
Courses
Seminars
Conventions
Celebrations
Research
Favorite Links
Contact Us
PhotoAlbum
Contact Us
Researches
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Scientific Publishing Center
Document Details
Document Type
:
Article In Journal
Document Title
:
Simultaneous Determination of Candesartan Cilexetil Cilexetil and Hydrochlorothiazide by by High-Performance Performance Liquid Chromatography
التقدير الكمي لعقار الكانديزرتان سيلكستيل و الهيدروكلوروثايزيد باستخدام كروماتوجرافيا السائل ذي الأداء العالي
Subject
:
Original Articles
Document Language
:
English
Abstract
:
A high performance liquid chromatographic method was developed for simultaneous determination of candesartan cilexetil and hydrochlorothiazide in binary mixtures and in pharmaceutical dosage forms. Active substances were separated by gradient system in the mobile phase, consisting of acetonitrile and 0.02M sodium acetate. The flow rate of the mobile phase was 1 mL/min. Separation was achieved on Kromasil 100 C18 column (4.6 mm i.d. × x 25 cm length, 5 µm). Detection was carried out using UV detector set at 265 nm. The detector response was linear in the range of 16- – 200 ng/injection (10 µl) for candesartan cilexetil and 12.5- – 1250 ng/injection (10 µl) for hydrochlorothiazide. The relative standard deviation of the recovered amounts of candesartan and hydrochlorothiazide were 0.27 and 0.60%, respectively. The limit of detections were 4 ± 0.05 and 5 ± 0.06 ng/injection for hydrochlorothiazide and, candesartan, respectively. The method was
ISSN
:
1319-1004
Journal Name
:
Medical Science Journal
Volume
:
15
Issue Number
:
2
Publishing Year
:
1429 AH
2008 AD
Number Of Pages
:
10
Article Type
:
Article
Added Date
:
Sunday, October 11, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
علاءالدين محمود خضر
Alaa E. M. Khedr
Researcher
Files
File Name
Type
Description
22277.pdf
pdf
Back To Researches Page