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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
PROTEASOME INHIBITOR NOVEL TREATMEN IN MULTIPLE MYELOMA
PROTEASOME INHIBITOR NOVEL TREATMEN IN MULTIPLE MYELOMA
Subject
:
Hematology
Document Language
:
English
Abstract
:
Multiple myeloma remains an incurable B-cell malignancy, necessitating urgent development of novel treatment. The proteasome is a ubiquitous and essential intracellular enzyme that degrades many proteins regulating cell cycle, apoptosis, transcription, cell adhesion, angiogenesis, and antigen presentation. PS-341 is a proteasome inhibitor that halts the cell cycle, resulting in apoptosis. It also inhibits a key transcription factor and has antiangiogenic activity and represents a novel potential anti cancer therapy. PS-341 has recently enrolled in many clinical trails for the treatment of multiple myeloma.
ISSN
:
1110-211X
Journal Name
:
Mansoura Medical Journal
Volume
:
36
Issue Number
:
1
Publishing Year
:
1426 AH
2005 AD
Article Type
:
Review Article
Added Date
:
Monday, May 12, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
فاتن السايس
Al-Sayes, Fatin
Investigator
Doctorate
محمود الاحول
Al-Ahwal, Mahmoud
Researcher
Doctorate
Files
File Name
Type
Description
Proteosome_Inhibitors_(27).pdf
pdf
مشاهدة المقالة العلمية كاملة
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