Main Page
About us
About the deanship
Vision
Mision
Quality policy
Deanship booklet
Research strategic construction
Employee list
Deanship consultants
Deanship agencies
Vice deanship for research groups
Vice deanship for research
Vice deanship of scientific research female
Research groups
Internal research programs
External research programs
Research groups prorgams
About research group programs
Active research groups
Guidelines for creating a new research group
Researcher services
Scientific instrument facilitating the publication
Abhathi portal
Plagiarism detection programs
Scientific journals
Research program forms
Researchers' inquiries
Research & scientific outcome
Digital media
Instruction guidelines
Research production for institutional finance
Activities & awards
Knowledge excellence awards
Knowledge excellence awards
Knowledge excellence awards winners
Excellence reward
Scientific research week
The fourteenth scientific research week
عربي
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Scientific Research
Document Details
Document Type
:
Project
Document Title
:
Design and preparation of derivatives Alaraluxykil Secretary of Kmmathlat Seeratonin Kmsknat to test their impact with potential use as anti-migraine
: تصميم و تحضير مشتقات الاريلوكسىالكيل امين كمماثلات للسيراتونين لاختبار تأثيرها كمسكنات مع احتمال استخدامها كمضادات للصداع النصفي
Document Language
:
Arabic
Abstract
:
We have found that the amendment in the structure of a compound Albroobranolol chemical - which is used in the medical field retardant receptor beta is also used as an adjunct in the treatment of migraine (migraine) as a result of its association with the weak Ptan future - h5-HT1B has resulted in vehicles Alaraluxykil secretary, which has a link to the largest relatively the same under the future but lack the selectivity and quality. So in this research was the preparation of compounds of the same group took into account the replacement of hydrogen at the site-α or-β in the group of alkyl side group, or methyl vinyl naphthalene in addition to the replacement of vinyl replacement sites in the 2.3 to 2.4 - 2.5 or 2 , 6 - Bhaloginat. Have been dating for new vehicles and precise quantitative analysis of nuclear magnetic resonance. And were also calculated for each characteristic fatty compound, as well as three-dimensional study of some vehicles and their conformity with the compound used model. Have been measured susceptibility number of vehicles in the link Ptan receptors 5-HT1b, 5-HT1d and found that some of his link to a high of more than a composite Albroobranolol Ptan future 5-HT1b a rate greater than the association Ptan future 5-HT1d and vice versa, which indicates the privacy of quality and selection of these vehicles. Also been tested for therapeutic effectiveness Kmsknat pain for a number of seven vehicles on the final laboratory rats and found to be effective, ranging from 66-100% compared to aspirin.
Publishing Year
:
1425 AH
2005 AD
Sponsor Name
:
kau
Sponsorship Year
:
1425 AH
2005 AD
Added Date
:
Wednesday, April 30, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عبدالقادر مختار إسماعيل
Ismaeil, abdulqader mokhtar
Investigator
Doctorate
Files
File Name
Type
Description
30712.docx
docx
Back To Researches Page